We Compared 50+ Nattokinase Supplements To Find The Best One For Artery & Circulation Support — Especially If Cholesterol & Plaque Are Already On Your Mind
Your Cholesterol Number Isn’t The Scariest Part. It’s What Could Be Happening Inside Your Arteries.
Millions of adults over 40 are watching their cholesterol, blood pressure, and heart health more closely than ever — and wondering what years of poor diet, stress, inactivity, or simply getting older may be doing inside their arteries.
The scary part is that you cannot look in the mirror and know how healthy your arteries are. You may feel completely normal while changes are happening inside your cardiovascular system. So people start eating cleaner, walking more, taking fish oil, CoQ10, or whatever “heart health” supplement they find online.
Eventually, many discover nattokinase. But that creates another problem.
Look at five different bottles and you might see 100mg, 200mg, 2,000 FU, 4,000 FU, or even 10,000 FU. Most people have no idea what those numbers mean, so they assume the biggest milligram number must be the strongest.
But nattokinase is an enzyme — and milligrams alone do not tell you how active that enzyme is.
Its activity is measured in FU, or fibrinolytic units. That matters because nattokinase is researched for its fibrinolytic activity and its role in supporting the body’s normal fibrin-turnover process. Two bottles can both say “Nattokinase” on the front while providing very different levels of enzyme activity.
And there is another problem. Healthy circulation is about more than one enzyme. Blood-vessel function, endothelial health, oxidative balance, and cardiovascular energy all matter too — yet many formulas stop with nattokinase alone.
That is why we looked past the flashy front labels and compared FU potency, formula quality, supporting cardiovascular ingredients, serving size, and overall value.
We compared popular nattokinase supplements from Double Wood, Micro Ingredients, NOW Foods, Nutricost, and Cleanora to see which ones actually stood out — and which ones looked a lot less impressive once we checked what was really inside.
We ranked the top 5 based on the following criteria:
FU Potency & Enzyme Activity
With nattokinase, milligrams do not tell the whole story. We looked closely at FU — fibrinolytic units — because FU tells you the enzyme activity being provided per serving. Products that clearly disclosed meaningful FU activity ranked higher than formulas relying on a big milligram number alone.
More Than Basic Nattokinase
Nattokinase is known for supporting normal fibrin turnover, but cardiovascular health involves more than one pathway. We gave extra consideration to formulas that also included targeted ingredients for blood-vessel function, endothelial support, oxidative balance and cardiovascular energy.
Formula Quality & Label Transparency
We looked past the marketing on the front of the bottle and checked what was actually inside. FU disclosure, serving size, supporting ingredients and overall formula design all mattered. Vague labels and oversized promises without enough detail counted against a product.
Serving Size & Overall Value
A cheap bottle is not always a better value. We compared what you actually receive per serving — including FU activity, the number of capsules required, the supporting formula and how much cardiovascular support you are getting for your money.
Things To Consider When Choosing The Best Nattokinase Supplement (FU Potency Matters More Than You Think)
Must-Haves
- ✓ Clearly Stated FU Activity Per Serving
- ✓ Meaningful Nattokinase Enzyme Potency
- ✓ Support Beyond Nattokinase Alone
- ✓ Ingredients Supporting Blood-Vessel Function
- ✓ Cardiovascular Energy & Antioxidant Support
- ✓ Clear Supplement Facts & Serving Information
- ✓ Simple Daily Serving Without Excessive Capsules
- ✓ Clear Safety & Medication Guidance
Red Flags
- ✗ Big Milligram Number With No Clear FU Activity
- ✗ Very Low Enzyme Activity Hidden Behind Marketing
- ✗ Basic Single-Ingredient Formula Sold As “Complete” Support
- ✗ Vague Ingredient Amounts Or Confusing Labels
- ✗ Requires A Handful Of Capsules Every Day
- ✗ No Clear Safety Information For Blood-Thinning Medications
- ✗ Extreme “Artery Cleansing” Or “Plaque Removal” Promises
- ✗ Paying More Without Getting More Formula Per Serving
After comparing FU potency, formula quality, supporting cardiovascular ingredients, serving size, and overall value, we narrowed the field down to the five nattokinase supplements that stood out most for daily circulation and cardiovascular support:
#1. Cleanora Nattokinase 10,000 FU
Of all the nattokinase formulas we compared, Cleanora stood out most clearly when we looked beyond the front of the bottle. It combines high nattokinase enzyme activity with a broader cardiovascular-support formula rather than relying on nattokinase alone.
The first thing that stands out is 10,000 FU per serving.
This is the number many shoppers miss. Nattokinase is an enzyme, so simply comparing milligrams does not tell you the whole story. FU — fibrinolytic units — measures enzyme activity. Cleanora clearly provides 10,000 FU per serving, making potency one of the strongest parts of the formula.
But the reason it ranked #1 was not just the FU number.
A lot of nattokinase products are extremely simple: nattokinase in a capsule, and that is essentially where the formula ends. Cleanora takes a broader approach by pairing nattokinase with ingredients selected around several areas of cardiovascular support.
Aged garlic, grape seed and pine bark add vascular support.
These plant-based ingredients are commonly researched in relation to blood-vessel and endothelial function, giving the formula a wider focus than normal fibrin turnover alone.
CoQ10 adds cardiovascular cellular-energy support.
Your heart is one of the most energy-demanding organs in your body. CoQ10 plays an important role in cellular energy production while also providing antioxidant support.
Turmeric and additional plant compounds round out the formula.
Cleanora also includes turmeric, bromelain and dandelion root alongside its core cardiovascular ingredients, creating a more comprehensive daily formula than a bare-bones nattokinase capsule.
And it stays simple to take.
Each bottle contains 60 vegetarian capsules, so you are getting a high-potency nattokinase formula without turning your daily routine into a handful of different bottles.
The bottom line: Cleanora did not win simply because it had the biggest-looking number. It ranked #1 because it paired 10,000 FU nattokinase with a broader formula designed around circulation, vascular function and cardiovascular support.
- 10,000 FU nattokinase per serving
- Supports normal fibrin turnover and healthy circulation
- Aged garlic for vascular-support positioning
- Grape seed and pine bark for endothelial and vessel support
- CoQ10 for cardiovascular cellular energy
- Turmeric and plant antioxidants for additional support
- 60 vegetarian capsules per bottle
- Broader formula than basic single-ingredient nattokinase
Pros
- ✓ High-potency 10,000 FU nattokinase per serving
- ✓ Goes beyond a basic single-ingredient nattokinase formula
- ✓ Includes aged garlic, grape seed and pine bark
- ✓ CoQ10 supports cardiovascular cellular energy
- ✓ Includes turmeric and bromelain
- ✓ Supports multiple areas of cardiovascular wellness in one formula
- ✓ Vegetarian capsule format
Cons
- ✗ Only Available Online — Not Sold In Retail Stores
- ✗ Often sells out due to high demand
Final Thoughts:
Cleanora was our #1 pick because it checks the boxes that mattered most in this comparison: clearly stated 10,000 FU activity, a broader cardiovascular formula, vascular-support ingredients and CoQ10 rather than nattokinase alone.
If you have looked at nattokinase before and wondered why one bottle costs more than another, the answer is not always found in the milligrams. FU activity and the rest of the formula matter too.
For someone who wants more than a basic single-ingredient nattokinase capsule, Cleanora offered the strongest overall combination of potency and complementary cardiovascular support among the formulas we compared.
#2. Double Wood Nattokinase 4,000 FU
Double Wood earned our #2 spot because it is one of the stronger straightforward nattokinase formulas we compared. Each daily two-capsule serving provides 4,000 FU of nattokinase, with 2,000 FU in each capsule.
Its biggest strength is transparency.
Double Wood publishes third-party testing for nattokinase activity, heavy metals and microbial contaminants, making it easier to see what you are actually getting instead of relying entirely on the claims printed on the front of the bottle.
Each bottle contains 120 capsules, which provides 60 full two-capsule servings at the listed 4,000 FU daily serving.
So why did it finish second?
The biggest limitation is that this is still essentially a nattokinase-only active formula. You get respectable enzyme activity, but you do not get the wider cardiovascular ingredient profile found in our top-ranked formula.
And while 4,000 FU is a solid level of nattokinase activity, it remains well below the 10,000 FU per serving provided by our #1 pick.
Double Wood is therefore a very good choice for someone specifically looking for a simple, tested nattokinase supplement — but it falls short if you want higher FU potency and broader cardiovascular support in the same formula.
Pros
- ✓ 4,000 FU of nattokinase per full serving
- ✓ 2,000 FU in each capsule
- ✓ 120 capsules per bottle / 60 full servings
- ✓ Third-party tested for nattokinase activity
- ✓ Heavy metal and microbial testing disclosed
- ✓ Vegan, non-GMO and gluten-free
Cons
- ✗ 4,000 FU per serving compared with 10,000 FU in our #1 pick
- ✗ Nattokinase-only formula with no added CoQ10, aged garlic, grape seed or pine bark
- ✗ Does not provide broader cardiovascular ingredients in the same formula
Final Thoughts:
Double Wood is one of the better straightforward nattokinase options we compared. The 4,000 FU serving and unusually transparent third-party testing earned it a strong second place. But if you want higher stated FU potency plus a broader cardiovascular formula instead of nattokinase alone, our #1 pick still has the advantage.
#3. Nutricost Nattokinase
Nutricost earned our #3 spot because it gives shoppers a straightforward nattokinase formula at an attractive value. The 2,000 FU version provides its full serving in just one capsule and gives you 120 servings in each bottle.
The biggest positive here is simplicity.
There is no complicated dosing schedule and Nutricost clearly states the nattokinase activity on the label. The product is also third-party tested through accredited laboratories, which is something we like to see when comparing daily supplements.
It is also vegetarian friendly, non-GMO and gluten free, making it an easy mainstream choice for someone who simply wants nattokinase without paying for a more elaborate formula.
But that simplicity is also why it finished behind our top two.
At 2,000 FU per serving, the standard formula provides half the daily activity of the 4,000 FU Double Wood serving and only a fraction of the 10,000 FU supplied by our #1 pick.
And just like many basic nattokinase supplements, the formula essentially stops with nattokinase. There is no added CoQ10, aged garlic, grape seed, pine bark or broader cardiovascular ingredient stack.
Nutricost is a strong value pick if simplicity and price matter most — but shoppers looking for higher enzyme activity and a more comprehensive cardiovascular formula may want to keep looking.
Pros
- ✓ 2,000 FU nattokinase per serving
- ✓ Only one capsule per serving
- ✓ 120 servings per bottle
- ✓ Third-party tested by accredited laboratories
- ✓ Non-GMO, gluten free and vegetarian friendly
- ✓ Strong value for a straightforward nattokinase formula
Cons
- ✗ Only 2,000 FU in the standard serving
- ✗ One-quarter the FU activity of our #1 pick
- ✗ Basic nattokinase formula without added cardiovascular-support ingredients
- ✗ No added CoQ10, aged garlic, grape seed or pine bark
Final Thoughts:
Nutricost is a respectable choice for someone who wants an affordable, straightforward nattokinase supplement. The one-capsule serving, transparent FU labeling and third-party testing are definite positives. But the lower enzyme activity and basic single-active approach prevent it from competing with the more comprehensive formulas at the top of our list.
#4. NOW Foods Nattokinase 100 mg
NOW Foods is one of the most recognizable names in the supplement industry, and its nattokinase formula is a straightforward, no-frills option. Each vegetarian capsule provides 100 mg of nattokinase standardized to 2,000 FU of enzyme activity.
There is plenty to like about the basics.
NOW clearly states the FU activity on the label, uses nattokinase derived from non-GMO soy, and the formula contains no vitamin K. It is also vegan, non-GMO and made without gluten.
The brand also offers both 60- and 120-capsule bottles, and the suggested use is one capsule one to two times daily on an empty stomach.
So why did such a recognizable brand finish lower on our list?
The biggest limitation is potency per serving. One capsule provides 2,000 FU. To reach 4,000 FU, you need to take two capsules — and even then, that is still well below the 10,000 FU provided by our #1 pick.
The formula also stops at nattokinase.
There is no CoQ10 for cardiovascular cellular-energy support, no aged garlic, and no grape seed or pine bark for additional vascular and endothelial support.
It also contains soy, which may rule it out for shoppers specifically looking for a soy-free formula.
NOW Foods remains a reasonable choice if you want a simple product from an established supplement company. But when we compared enzyme activity and overall formula depth, it simply did not offer as much as the products ranked above it.
Pros
- ✓ 2,000 FU clearly disclosed per capsule
- ✓ Established and widely recognized supplement brand
- ✓ Nattokinase derived from non-GMO soy
- ✓ Contains no vitamin K
- ✓ Vegan / vegetarian capsule
- ✓ 60- and 120-capsule sizes available
Cons
- ✗ Only 2,000 FU per one-capsule serving
- ✗ Requires two capsules to reach 4,000 FU
- ✗ No added CoQ10, aged garlic, grape seed or pine bark
- ✗ Basic single-active formula rather than broader cardiovascular support
- ✗ Contains soy
Final Thoughts:
NOW Foods is a dependable basic option from a well-established brand. The clearly stated 2,000 FU activity, simple one-capsule serving and no-vitamin-K formula are positives. But shoppers looking for higher nattokinase activity and a broader cardiovascular-support formula will find significantly more in the products ranked above it.
Cleanora Nattokinase 10,000 FU
- 10,000 FU Nattokinase Per Serving — high enzyme activity clearly stated on the label
- More Than Basic Nattokinase — combines nattokinase with complementary cardiovascular-support ingredients
- CoQ10 + Aged Garlic + Grape Seed + Pine Bark — broader support for cardiovascular energy, vascular function and antioxidant balance
- 90-Day Money-Back Guarantee — extra time to decide whether Cleanora is right for you
FREQUENTLY ASKED QUESTIONS
What you should know about nattokinase, 10,000 FU, circulation and choosing stronger daily cardiovascular support.
Can Cleanora help if I'm worried about clogged arteries and poor circulation?
Yes — if your goal is to support healthier circulation and vascular function, that is exactly what Cleanora was formulated around.
Its centerpiece is 10,000 FU of nattokinase per serving, an enzyme researched for fibrinolytic activity and its role in supporting your body's normal fibrin-turnover process.
Cleanora then goes further with aged garlic, grape seed, pine bark and CoQ10 for broader vascular, endothelial and cardiovascular support.
One important distinction: nattokinase and arterial plaque are not the same thing. Cleanora is designed to support cardiovascular wellness; it is not a treatment that physically removes diagnosed arterial plaque or replaces medical care for a blocked artery.
Is 10,000 FU really a big deal?
Yes. With nattokinase, FU is one of the most important numbers on the bottle.
Nattokinase is an enzyme. Milligrams tell you how much material is present, while FU — fibrinolytic units — tells you the enzyme activity.
That is why two bottles can both say “nattokinase” and still be very different products.
Cleanora provides 10,000 FU per serving. Many basic options we compared provide around 2,000 FU.
Why shouldn't I just buy a cheaper 2,000 FU nattokinase?
You can — but you're not buying the same type of formula.
Many cheaper products give you a basic 2,000 FU nattokinase capsule and stop there.
Cleanora gives you 10,000 FU per serving and combines it with CoQ10, aged garlic, grape seed, pine bark, turmeric and additional supportive ingredients.
So if all you want is the cheapest nattokinase capsule, a basic formula may be enough. If you want higher stated enzyme activity plus broader cardiovascular support in one formula, that's where Cleanora stands apart.
Does Cleanora support more than just blood flow?
Yes. That's one of the biggest reasons we preferred it over basic nattokinase formulas.
Nattokinase supports normal fibrin turnover and healthy circulation, while CoQ10 supports cardiovascular cellular energy.
Aged garlic, grape seed and pine bark broaden the formula toward blood-vessel and endothelial support, while turmeric contributes antioxidant and inflammatory-balance support.
In other words: you're not relying on one ingredient to do everything.
Will I actually feel Cleanora working?
You shouldn't expect a dramatic “my arteries just opened” feeling — and that's actually a good thing.
Cleanora is designed for consistent daily cardiovascular support, not a temporary stimulant-like sensation.
Your experience can vary based on age, diet, activity, medications and overall health, so consistency matters more than chasing an immediate feeling after one serving.
Is Cleanora difficult to add to my daily routine?
No. It was designed to give you multiple cardiovascular-support ingredients in one formula instead of buying bottle after bottle separately.
Simply follow the serving directions on your Cleanora bottle and take it consistently.
More is not automatically better, especially with nattokinase, so stick with the labeled serving unless your healthcare professional advises otherwise.
What if I buy Cleanora and decide it isn't for me?
You have 90 days to decide.
Cleanora is backed by a 90-day money-back guarantee, giving you far more time than a typical short trial to see whether you want it as part of your cardiovascular routine.
If you're not satisfied, follow Cleanora's return instructions within the guarantee period to request your refund.
Why add CoQ10, aged garlic, grape seed and pine bark to nattokinase?
Because cardiovascular health is bigger than one enzyme.
Nattokinase gives Cleanora its high-FU fibrinolytic activity. CoQ10 adds cardiovascular cellular-energy support. Aged garlic, grape seed and pine bark broaden the formula toward vascular, endothelial and antioxidant support.
That's the whole philosophy behind Cleanora: don't stop at nattokinase when you can support multiple areas of cardiovascular wellness in the same daily formula.
So who is Cleanora Nattokinase really for?
It's for adults who are done ignoring their circulation and cardiovascular health and want to be more proactive about supporting it.
If you've started thinking more seriously about your arteries, blood-vessel health, circulation or what years of aging, stress and lifestyle may mean for your cardiovascular system, Cleanora gives you a high-potency option built around those concerns.
Instead of a bare-bones 2,000 FU capsule, you get 10,000 FU nattokinase plus a broader cardiovascular-support stack in one formula.
Worried About Your Arteries? This Is The Formula We'd Choose.
If years of aging, stress, poor diet or inactivity have made you start thinking more seriously about circulation, artery health and your cardiovascular future, Cleanora is the formula that stood out. Instead of giving you a basic low-potency nattokinase capsule, it combines 10,000 FU enzyme activity with broader vascular and heart support.
- 10,000 FU Nattokinase Per Serving — five times the stated enzyme activity of many basic 2,000 FU formulas
- Supports Healthy Circulation & Normal Fibrin Turnover — the reason FU activity matters in the first place
- Broader Blood-Vessel Support — aged garlic, grape seed and pine bark support vascular and endothelial function
- CoQ10 + Turmeric For Added Cardiovascular Support — supporting cellular energy and antioxidant balance instead of relying on one ingredient alone
- 90-Day Money-Back Guarantee — plenty of time to decide whether Cleanora belongs in your daily routine
DISCLAIMER: The information presented on this page is for educational and informational purposes only. Individual experiences and results may vary.
This page contains promotional content and may be considered an advertorial. Product rankings, comparisons and opinions reflect the criteria described on this page and should not be interpreted as medical advice.
Statements regarding dietary supplements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
If you take prescription medications — particularly anticoagulants, antiplatelet medications, aspirin or blood-pressure medications — consult a qualified healthcare professional before using nattokinase.
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